open access

Introduction

The medical term for lazy eye is “amblyopia.” Related to developmental problems in the brain, Amblyopia affects 2-5 percent of children and occurs when the brain favors one eye, often due to poor vision in the other eye. The root cause is due to nerve pathways in the brain that process sight, not functioning properly leading the eyes to not receive equal amounts of use and eventually causing the brain to ignore signals from the weak, or “lazy,” eye. The condition can result in vision impairment and loss of depth perception. If left untreated, temporary or permanent loss of vision can occur. This can include loss of both depth perception and 3-D vision. Early treatment is best as getting the eyes to work as a team becomes harder as the child grows and treatment started after 7-10 years of age may not work at all. Investigative Ophthalmology & Visual Science reported in 2008 that vision and fine motor skills were tested in a group of children with Amblyopia of various causes, compared to children without the disorder. Fine motor skills were determined to be reduced in children with amblyopia, particularly those with strabismus, compared with control subjects. The deficits in motor performance were greatest on manual dexterity tasks requiring speed and accuracy.

Case Presentation

We present a case of a six year old female born at 36 weeks and spent 10 days in NICU. On April 9, 2019 the child was found to have a lazy eye with documented vision of 9/200 in her left eye. She also had difficulties in coordinating her right upper extremity. The Grandmother of the child had been patching the good eye for 2 hours each day in an effort to strengthen the weaker eye. On May 9, 2019, the child was treated with 4.8 ml of Stemell exosomes IV and 0.2 ml of Stemell exosomes intranasal. On May 10, 2019, the child was treated with 0.2 ml of Invitrx cord tissues intranasal and 0.8 ml IM. On May 14, 2019 the child’s grandmother patched the right eye, which was her good eye, and the patient reported that she could see clearly. On May 17, 2019 the patient was evaluated by the ophthalmologist and her vision was tested at 20/50 which is a dramatic improvement. The patient has also experienced improved coordination in her upper extremity.

Conclusion

The results of this study suggest that exosomes administered both intranasal and intravenous can play a crucial role in the improvement of symptoms associated with Amblyopia. This study reaffirms the need to look outside of simple eye exercises, eye drops or surgery as the only solutions for this condition. Exosomes appear to play a critical role in regenerating the nerve pathways allowing the eyes to begin working together thereby balancing out the strength in each eye, improving vision and fine motor skills.

References

1. Webber A, Wood J, Gole G, Brown B. (2008). The effect of amblyopia on fine motor skills in children. Investigative Ophthalmology & Visual Science. 48, 594-603.